منابع مشابه
VEGFR2 trafficking: Speed doesn’t kill
Vascular endothelial growth factor-A (VEGF-A) plays a central role in formation of the blood vasculature. The growth factor acts on endothelial cells via a receptor tyrosine kinase, VEGF receptor 2 (VEGFR2) and a non-tyrosine kinase receptor neuropilin-1 (NRP1). Both of these are vital to VEGF-A signaling as a deletion or mutations in either receptor lead to a variety of vascular defects. Given...
متن کاملAirway narrowing in asthma: does speed kill?
THERE IS WIDESPREAD AGREEMENT that shortening of airway smooth muscle is the proximal cause of excessive airway narrowing during an asthma attack, with swelling of airway wall compartments and plugging by airway liquid or mucous being important amplifying factors (15, 18, 29). But it remains unclear why in asthma the muscle can shorten excessively. The oldest and certainly the simplest explanat...
متن کاملSmall GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.
The devastating sequelae of diabetes mellitus include microvascular permeability, which results in retinopathy. Despite clinical and scientific advances, there remains a need for new approaches to treat retinopathy. Here, we have presented a possible treatment strategy, whereby targeting the small GTPase ARF6 alters VEGFR2 trafficking and reverses signs of pathology in 4 animal models that repr...
متن کاملVEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses. Activated VEGFR2 undergoes ubiquitination but the enzymes that regulate this post-translational modification are unclear. In this study, the de-ubi...
متن کاملKIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.
Although the trafficking of newly synthesized VEGFR2 to the plasma membrane is a key determinant of angiogenesis, the molecular mechanisms of Golgi to plasma membrane trafficking are unknown. Here, we have identified a key role of the kinesin family plus-end molecular motor KIF13B in delivering VEGFR2 cargo from the Golgi to the endothelial cell surface. KIF13B is shown to interact directly wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.25536